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18Jun

USDTL is a proud member of WBENC!

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USDTL is a proud member of The Women’s Business Enterprise National Council (WBENC). WBENC is a non-profit organization that is dedicated to helping women-owned business, like USDTL, thrive. As a member of WBENC, we have a mutual belief that diversity promotes innovation, open doors, and creates partnerships that help fuel the economy.

As a certified Women’s Business Enterprise, or WBE, USDTL went through a rigorous and stringent certification process to confirm that the business is owned, managed, and controlled by a woman or women. As a nationally certified WBE, we are able to network with other WBEs and collaborate with women-owned businesses to develop a mutually beneficial relationship.

To learn more about WBENC, visit https://www.wbenc.org/.

17Jun

ToxTime: Drug Trends & Concerns Regarding NAS

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USDTL hosted an online Webinar, titled ToxTime, where we discussed Drug Trends and Concerns Regarding Neonatal Abstinence Syndrome (NAS).

The Webinar discussion included:

  • A Brief Overview of NAS
  • Withdrawal Symptoms
  • Drug Withdrawal Variance
  • USDTL Observations & Growing NAS Concerns
  • Breaking the Stigma at Lily’s Place, a NAS Center

Click Here to View the Webinar

USDTL hosted an online Webinar, titled ToxTime, where we discussed Hair and Nail Testing – What’s the Difference?

The guest speaker was Joseph Jones, Ph.D., NRCC-TC, Chief Operating Officer at USDTL.

The webinar includes discussion around the following points:

  • How Fingernail specimens can complement a hair testing program
  • Using Fingernail as an alternative specimen type      
  • The difference in detection windows of Hair and Fingernail Specimens
  • Case reports using both Hair and Fingernail specimens

Click Here to View the Event

 

    USDTL hosted an online Webinar, titled ToxTime, where we discussed Environmental Exposure Drug Testing 101 (ChildGuard®). The guest speaker was Joesph Jones, Ph.D., NRCC-TC, Chief Operating Officer at USDTL.

     The Webinar discussed why ChildGuard® was developed, and the value it brings to clients. Other points of discussion include:

  • How drugs are incorporated in hair
  • How fingernails can be used
  • Legal defensibility of ChildGuard®
  • Trends in ChildGuard® testing

The full webinar is available to watch below. 

17Mar

Coffee Tox: Missed Opportunities

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                USDTL hosted an online Webinar, titled Coffee Tox, where we discussed Missed Opportunities in Newborn Drug Testing. The guest speakers were Colleen Cusack, Client Services Specialist at USDTL and Kristen Moore, MSN, RNC-OB, C-EFM, Director of Maternal Services at Union Hospital.

                Colleen Cusack is USDTL’s Client Services Specialist.  Colleen has 15 years of Client Services experience and has been with USDTL for 8 years.  She consistently goes above and beyond to assist and advocate for the client.  Colleen has clear communication skills, strives to practice active listening, is empathic, and is very knowledgeable.  She plays a key role in improving the client’s experience and makes an impact on USDTL’s vision of Protecting and Enriching Lives

                Kristen Moore is a perinatal nurse experienced in providing optimal care to women with normal and complicated pregnancies. She has worked as a unit-based educator, clinical manager, chief nurse consultant for the Department of Health, and now serves as the Director of Maternal Child Services at Union Hospital in Terre Haute, Indiana. Kristen’s hospital began umbilical cord screening in November of 2020. Her team states they have experienced drastically improved reporting times with cord screening versus meconium, as well as other benefits including ease in collection and guaranteed availability of testing for all patients.

                The Webinar discussed why universal collection is important in newborn drug testing, and the value it brings to hospitals. Other points of discussion include:

  • Meconium and umbilical cord testing
  • How rejections have improved with umbilical cord testing
  • Criteria for testing
  • Importance of obtaining an accurate history of abuse
  • Testimonies and stories

The full webinar is available to watch below. 

15Feb

Winter Weather Delays

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Due to current weather conditions, we are experiencing courier delays in receiving specimens into the laboratory, this will cause a delay in reporting out some results. As always, we will do our best to process specimens as quickly as possible and get your reports to you as soon as we can.

Thank you for understanding. If you are also affected by the weather conditions please be safe out there. 

 

08Jul

Identifying the Indiscernible Isotonitazene (iso)

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Identifying the Indiscernible Isotonitazene (iso)

by: Kelly Hack

Another potent synthetic opioid has recently been identified­ and is creating significant concern among those in the forensic toxicology and law enforcement realm. According to The Center for Forensic Science Research & Education (CFSRE), Isotonitazene (iso) is a synthetic opioid derived from etonitazene, which is a national and international controlled substance that was first synthesized in the 1950s but denied approval for medical use due to the extreme potency of the substance. Iso shares a similar chemical structural resemblance to etonitazene and has been claimed to be more potent than fentanyl and 100 times more powerful than morphine. The emergence of this drug has public health and safety, law enforcement, laboratory personnel, and medical examiners on high alert. In August 2019, eight blood specimens associated with postmortem death investigations identified iso in their toxicology reports.

According to an article by USA Today, alarming data regarding this novel opioid has been documented with recent overdose deaths in Indiana and Illinois. Blood samples taken from these overdose death victims identified the presence of iso leading to conclusions that iso is unknowingly being cut into substances such as cocaine. In 2018, 713 overdose deaths in Indiana involved synthetic opioids like iso, generating a death rate of 11.5 deaths per 100,000 persons compared with the national rate of 9.9.

Medical Express, recently wrote an article explaining that similar to fentanyl, iso is quite lethal, as a minute amount can trigger a near-instant overdose. Iso, due to its slight chemical structural difference remains legal at the national level. Despite the United States’ efforts on prohibiting any distribution of fentanyl from China, chemists are eagerly replacing their demand by utilizing similar derivatives. Iso can be identified as a yellow or off-white powder and is cut into other substances and pressed into counterfeit pills without the user’s awareness.

An article written by Bridges of Hope Rehab Treatment Center, it notes that similar to fentanyl, many people who are overdosing from iso are not aware their substances are tainted with this fatal additive. It also discusses adding iso to drug supplies, amplifies substance use disorder (SUD) by increasing one’s tolerance and dependence.

Gabapentin, An Emerging Threat in Today’s Opioid Epidemic

by: Kelly Hack

Gabapentin prescribing increased 64 percent from 39 million prescriptions in 2012 to 64 million by 2016, becoming the 10th most commonly prescribed medication in the United States.1

A recent study from the American Journal of Psychiatry disclosed that the number of Appalachian drug users who reported using gabapentin to get “high” has increased nearly 30-fold from 2008-2014.2 These alarming statistics among other supporting data significantly contributes to the reality that gabapentin is now considered an emerging threat in today’s opioid epidemic.4

What is Gabapentin?

Gabapentin, a gamma-aminobutyric acid (GABA) analog was originally developed as an anticonvulsant and prescribed as an analgesic for neuropathic pain. It is currently sold under the brand names: Neurontin®, Gralise®, Horizant®. The medication is also prescribed as an off-label medication for the treatment of migraines, mental illness, and fibromyalgia. Gabapentin first approved in the United States in 1993 with minimal potential for misuse is now classified as a controlled substance and a current drug of abuse.2 Gabapentin’s effects on the central nervous system including drowsiness and low-level euphoria have been recognized within the addiction community to enhance the euphoric effects of heroin and when consumed exclusively in high doses, produces a marijuana-like high.2 A study from 2016 found that gabapentin misuse was only 1 percent among the general population, however for those that misuse opioids, gabapentin misuse significantly increased to 15-22 percent.3

Side Effects

  • Viral infection
  • Fever
  • Nausea and vomiting
  • Trouble speaking
  • Hostility
  • Jerky Movements4

Gabapentin Overdoses

In 2017, 70,237 drug overdose deaths occurred in the United States, and a vast majority of those fatalities were directly related to opioids.1 In efforts to significantly reduce opioid abuse, providers began to increase their prescribing of gabapentin, with the understanding that the medication was a safer alternative to opioids for the management of acute pain. However, during 2013-2017, 74,175 gabapentin exposures were reported to poison control centers (PCCs) and a clear correlation was documented that the increase of accessibility to gabapentin directly increased toxic exposures.

According to data from the Louisville coroner’s office in Kentucky, gabapentin was found in nearly one-fourth of all overdoses. Throughout the state, the drug is now showing up in about 1 in every 3 overdose deaths.3 Due to the alarming rates of reported overdoses associated with gabapentin, states including Tennessee and Michigan have reclassified the drug as a Schedule V Controlled Substance. Massachusetts, Minnesota, Nebraska, North Dakota, Ohio, Virginia, West Virginia, and Wyoming also require reporting of gabapentin prescriptions through the Prescription Drug Monitoring Program (PDMP) database.

Respiratory Depression and Withdrawal

Drug-induced respiratory depression has been well documented with gabapentin use. The Federal Drug Administration (FDA) now requires new warning labels on all gabapentinoids regarding potential respiratory depressant effects. There is an increased risk for serious breathing difficulties among patients who use gabapentanoids alone or with other drugs that depress the central nervous system (CNS). Patients with a preexisting respiratory impairment such as chronic obstructive pulmonary disease (COPD) also have an augmented risk for experiencing respiratory distress with gabapentanoid usage.6 Additional health complications affiliated with continued gabapentin use occur with abrupt discontinuation of the medication, which has been documented to often mirror symptoms of those withdrawing from alcohol and benzodiazepines.7

Withdrawal Symptoms

  • Anxiety
  • Irritability
  • Agitation
  • Confusion
  • Tachycardia
  • Catatonia7

Co-Prescribing

Since gabapentin and opioids have historically been prescribed for pain, co-prescription of these two medications is quite prevalent. In a population-based nest case-control study among opioid users who were residents of Ontario, Canada between August 1, 1997, and December 31, 2013, it was found that among patients receiving prescription opioids, gabapentin was concomitant with a substantial increase to opioid-related deaths.5 The primary analysis of the study conveyed that the likelihood of opioid-related death was 49 percent higher among individuals exposed to gabapentin and opioids in comparison to those exposed to opioids solely.5 Approximately 8 percent of patients from the study receiving opioids were co-prescribed gabapentin and that co-prescription was directly linked to a 50 percent increase in death probability. Overall, similar studies conducted within the United States and the United Kingdom have drawn parallel conclusions that between 15 and 22 percent of people with opioid use disorder (OUD) are also misusing gabapentin.5

“Misuse of gabapentin is just one more collateral effect of the opioid epidemic. When one drug becomes less available, drug users historically seek out alternatives,” said Caleb Alexander, an epidemiologist at Johns Hopkins University.

In Utero Exposure

Studies are finding a definitive correlation to gabapentin and opioid use among pregnant mothers, as increases in co-exposure, are documented. In a study of 19 infants born to mothers who used opioids and gabapentin during pregnancy, 10 percent of those babies developed Neonatal Abstinence Syndrome (NAS). The failure to control gabapentin withdrawal symptoms with methadone exclusively, lead to gabapentin and methadone being administered congruently. The response from this combined medication-assisted treatment (MAT) showed rapid improvement with newborn withdrawal, indicating that the combined usage of opioid and gabapentin during pregnancy is evident.8

It is imperative that testing for licit drugs such as gabapentin becomes part of a healthcare system’s newborn toxicology testing protocol. It is our goal to continually adapt our offerings to support the systems that are addressing these issues for their population health.

Gabapentin Testing

We offer gabapentin testing in umbilical cord tissue. This specimen type captures substances in the newborn’s system up to approximately 20-weeks prior to birth. We also offer gabapentin testing in hair and nail. Hair offers a window of detection of up to approximately 3-months. Nail offer a windows of detection of up to approximately 3-6 months.

As a leader in forensic toxicology, it is our mission to provide the most comprehensive testing panels to meet the needs of our clients and to proactively address the current trends in today’s substance abuse landscape.


References

  1. Reynolds, K., Kaufman, R., Korenoski, A., Fennimore, L., Shulman, J. and Lynch, M. (2019). Trends in gabapentin and baclofen exposures reported to U.S. poison centers. [online] Taylor & Francis. Available at: https://www.tandfonline.com/doi/full/10.1080/15563650.2019.1687902 [Accessed 14 Feb. 2020].
  2. Vestal, C. (2018). Abuse of Opioid Alternative Gabapentin Is on the Rise. [online] Pewtrusts.org. Available at: https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2018/05/10/abuse-of-opioid-alternative-gabapentin-is-on-the-rise [Accessed 14 Feb. 2020].
  3. Mammoser, G. (2019). Opioid Overdoses and Gabapentin. [online] Healthline. Available at: https://www.healthline.com/health-news/gabapentin-latest-pain-medication-in-opioid-overdoses [Accessed 14 Feb. 2020].
  4. Healthline. (n.d.). Gabapentin: Side Effects, Dosage, Uses, and More. [online] Available at: https://www.healthline.com/health/gabapentin-oral-capsule [Accessed 14 Feb. 2020].
  5. Gomes, T., Juurlink, D., Antoniou, T., Mamdani, M., Paterson, M. and Brink, W. (2017). Gabapentin, opioids, and the risk if opioid-related death: A population-based nested case-control study. [online] Public Library of Science. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626029/ [Accessed 14 Feb. 2020].
  6. U.S. Food and Drug Administration. (2019). FDA requires new respiratory depression risk gabapentinoids warnings. [online] Available at: https://www.fda.gov/news-events/fda-brief/fda-brief-fda-requires-new-warnings-gabapentinoids-about-risk-respiratory-depression [Accessed 15 Feb. 2020].
  7. Medscape. (2010). Withdrawal Symptoms After Gabapentin Discontinuation. [online] Available at: https://www.medscape.com/viewarticle/722526 [Accessed 15 Feb. 2020].
  8. Loudin, S., Murray, S., Prunty, L., Davies, T., Evans, J. and Werthammer, J. (2017). An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids. [online] jpeds.com. Available at: https://www.jpeds.com/article/S0022-3476(16)31232-X/fulltext [Accessed 17 Feb. 2020].