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USDTL Research

“Bath Salts” may be as Addictive as Meth or Cocaine

Initial Studies Show Substituted Cathinones Informally Known as “Bath Salts” may be as Addictive as Meth or Cocaine
By Douglas Lewis, DSc, President, Scientific Director, USDTL

At this year’s 74th Annual College on Problems of Drug Dependence Meeting (CPDD) in LaQuinta, California the pharmacology of “Bath Salts” was addressed in several scientific presentations. “Bath Salts” are a series of substituted cathinone compounds that have been marketed primarily as “Not for Human Consumption” products to avoid legal constraints.

These studies of the basic pharmacological properties of these arrays of compounds suggest that as a group, the substituted cathinones from mephedrone to MDPV to 4-FMC, etc. all produced significant increases in locomotor activities in rats and mice, were all potent reinforcers of behaviors and appeared to produce their own individual forms of behavioral toxicity on a scale not less damaging than cocaine or methamphetamine.

While the data sets are still quite thin, this early data along with the empirical data from “the street” in the form of ER admissions and Poison Control Center calls indicates that the substituted cathinones are anything but safe, legal highs as some internet sites suggest.

Study Describes Illicit Use of Buprenorphine Among Nonmedical Users of Opioids in Ohio

While buprenorphine misuse has been reported in many states, most studies have focused on opioid-dependent individuals, heroin users, and/or those in treatment. For example, an Ohio study of treatment providers, law enforcement officials, and drug users recruited through treatment programs found evidence of increasing buprenorphine misuse (see CESAR FAX, Volume 21, Issue 2). New research in Ohio now provides evidence of illicit use of buprenorphine among a population not previously studied—young adults not involved with heroin or injection drug use nor dependent on pharmaceutical opioids.

Following are findings from this community-recruited sample of young adults from the Columbus, Ohio area:

Knowledge About Buprenorphine:

The majority of users reported that when they were first introduced to buprenorphine they had limited knowledge about the drug. Some had no idea it was used to treat opioid dependence and were told that it would work like any other pain pill.

Street Availability:

While the majority of respondents reported that buprenorphine was more difficult to obtain than more commonly used prescription opioids (such as oxycodone or hydrocodone), several respondents reported that they felt the popularity of and demand for buprenorphine has been rising. Friends or acquaintances who were addicted to prescription opioids or heroin and networks of users with legitimate prescriptions were the most common sources of illicitly used buprenorphine. In fact, some users “expressed a belief that buprenorphine doses prescribed by physicians were too high for most patients who needed much lower amounts to control their withdrawal symptoms” (p. 205).

Use to Get High:

While approximately one-half said that they took buprenorphine to get high, the reported effects ranged from no effect to too intense. Those who used buprenorphine to get high typically used it on very few occasions, either because the street availability was limited or they did not get the euphoric effects they expected or wanted. Some believed that you need to inhale buprenorphine and/or have a low tolerance to opiates to get high.

Use to Self-Medicate:

About one-half reported using buprenorphine to self-medicate withdrawal symptoms, using the drug regularly to replace their preferred opiates, to reduce their illicit pain pill use, or to quit altogether. Self-medication was preferred to going to a substance abuse treatment program because of the high cost of buprenorphine-based treatment at primary care, waiting lists at publicly-funded facilities, and the stigma related to seeking drug treatment.

SOURCE: Adapted by CESAR from Daniulaityte, R., Falck, R., and Carlson, R.G., “Illicit Use of Buprenorphine in a Community Sample of Young Adult Non-Medical Users of Pharmaceutical Opioids,” Drug and Alcohol Dependence 122(3):201-207, 2012.


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