Maternal cocaine use without evidence of fetal exposure

J Pediatr. 1994 Oct;125(4):652-4.
Potter S, Klein J, Valiante G, Stack DM, Papageorgiou A, Stott W, Lewis D, Koren G, Zelazo PR.
Department of Psychology and Research Institute, McGill University, Montreal, Canada. DOI: 10.1016/s0022-3476(94)70029-x

We report a case of lack of fetal exposure to cocaine and benzoylecgonine as evidenced by meconium and hair analysis, but exposure to nicotine and its metabolite cotinine, after extensive maternal use of cocaine and nicotine. These data suggest that the mode of maternal use of cocaine and individual differences in placental handling of the drug may protect some fetuses, and highlight the need to address interpatient variability.