The detection of oxycodone in meconium specimens.


J Anal Toxicol. 2005 Jan-Feb;29(1):54-7.

 

Le NL, Reiter A, Tomlinson K, Jones J, Moore C.

U.S. Drug Testing Laboratories, 1700 S. Mount Prospect Road, Des Plaines, Illinois 60018, USA.

A procedure for the determination of oxycodone in meconium using direct ELISA microplate technology followed by electron impact gas chromatography-mass spectrometry (GC-MS) is described for the first time. The abuse of oxycodone (OxyContin) has been widely discussed in mainstream media, and it has been described as a cheap form of heroin. Oxycodone has been reported as having a high degree of abuse and potential complications in neonates from maternal drug use. Using a standard enzyme multiplied immunoassay screening technology, the cross-reactivity of oxycodone to the morphine antibody is only 5-6%. A positive screening value would require a high concentration of drug to be present, so a protocol for the detection of oxycodone in meconium using a direct ELISA microplate immunoassay followed by GC-MS was developed. The assay is now routinely used in our laboratory.

PMID: 15808014 [PubMed - indexed for MEDLINE]